Softisan 649 is used as a lanolin substitute and as a cream base in cosmetics, skin care, baby creams, decorative cosmetics and hair care products. Softisan 649 ioi oleo datasheet cosmetics specialchem. Innovators of the first hour with the vision of mr. Today equipped with first class gmp certified production, ioi oleo gmbh part of ioi oleochemicals group since 2015 proudly produces in germany the highest quality of esters. Sasols softisan 649 is a partial ester of diglycerin with medium chain fatty acids, isostearic acid, 12hydroxystearic acid and adipic acid. Softisan 649 familiarize yourself with this chemical and. An intranasal irritation assessment of antibacterial ointment alone or in combination with mupirocin versus bactroban nasal. Jp5322198b2 jp2007246779a jp2007246779a jp5322198b2 jp 5322198 b2 jp5322198 b2 jp 5322198b2 jp 2007246779 a jp2007246779 a jp 2007246779a jp 2007246779 a jp2007246779 a jp 2007246779a jp 5322198 b2 jp5322198 b2 jp 5322198b2 authority jp japan prior art keywords oil wax melting point gloss viscosity prior art date 20070925 legal status the legal status is an. One additional group of six animalssex served as the control and received the vehicle, petrolatumsoftisan 649.
Imhausen in 1912, our specialty ingredients imwitor, miglyol, softigen, dynasan and witarix inspire trust and costeffective reliability. Spezialol 107 triheptanoin oily liquid 20 neutral, stable, penetration enhancer, solvent, dermal applications. Patient information sheet softisan 649 s016 your patch testing results indicate that you have a contact allergy to softisan 649. Their versatile properties including refatting, wetting performance and antimicrobial activity make them multifunctional ingredients for a. The product is nonocclusive and in comparison to lanolin oil virtual odorless. Scan to pdf as a replacement for softi were a completely separate company to softi. Of course, if you are using the softi software in your business and cant get help or advice about the software then that could cause problems for you were you to need support. Semisolid lanolin substitute with high water binding capacity and good adhesion to skin.
You can filter the products according to specific attributes. The product is nonocclusive and in comparison to lanolin virtually odorless. The information and materials provided is for educational purposes only. Application of the substance the mixture additive for cosmetic or pharmaceutic preparations details of the supplier of the safety. This collection of guideline formulation examples provides an overview of how the wide range of sasol raw materials can be used to fulfil your performance and formulation requirements. Us5594026a us08424,684 us42468495a us5594026a us 5594026 a us5594026 a us 5594026a us 42468495 a us42468495 a us 42468495a us 5594026 a us5594026 a us 5594026a authority us united states prior art keywords mupirocin polymorph form crystalline form iii prior art date 19901211 legal status the legal status is an assumption and is not a legal. Softisan 649 is miscible with fats, oils and paraffin hydrocarbons, and as such is very compatible with consistency regulators such as cetyl alcohol, stearic acid, beeswax, petrolatum or triglycerides. Division of dermatology, department of medicine, university of california, san diego, ca 92103. Phase behavior characterization of ointments containing lanolin or a lanolin substitute david w. Softisan 649 1 bisdiglyceryl polyacyladipate2 10,00 cremervero shea butter1 butyrospermum parkii butter 30,00. What mupirocin looks like and contents of the pack mupirocin is a smooth white ointment. Softisan 649 is a partial ester of diglycerin with medium chain fatty acids, isostearic acid, stearic acid, 12 hydroxystearic acid and adipic acid.
In the second study the sensitization to glyceryl monothioglycolate gmt was assessed based on the report of storrs 1984 that this ingredient of acid permanent waves is a much more relevant sensitizer than ammonium. What bactroban nasal ointment looks like and contents of the pack on rare occasions, medicines like bactroban can cause inflammation of the colon large intestine, causing diarrhoea, usually with blood and mucus, stomach pain, fever pseudomembranous colitis. Shaw division of dermatology, department of medicine, university of california, san diego, ca 92103. As a mul func onal cream base, it has similar proper es to petrolatum. Glaxo wellcome operations, harmire road county durham, dl12 8dt barnard castle, uk. Buy softisan 649 online now at trulux, the bulk cosmetics ingredients specialist. Softisan 649 by ioi oleo acts as a filmforming agent. Softisan 649 is a partial ester of diglycerin with mediumchain fatty acids, isostearic acid, stearic acid, 12hydroxystearic acid and adipic acid and can be used in a variety of personal care applications in the form of ow or wo emulsions as well as waterfree formulations. Appropriate proportions of white soft paraffin and softisan 649 were heated together until molten 6070 c. Bisdiglyceryl polyacyladipate2 and bisdiglyceryl polyacyladipate1 are mixed fatty acid esters. Box 147 calgon vestal laboratories, st louis, mo, 631660147 pages 12832. Us4790989a us07036,929 us3692987a us4790989a us 4790989 a us4790989 a us 4790989a us 3692987 a us3692987 a us 3692987a us 4790989 a us4790989 a us 4790989a authority us united states prior art keywords salt mupirocin composition method pseudomonic acid prior art date 19860626 legal status the legal status is an assumption and is not a legal conclusion. Softisan 649, an oilinwater cream with polyethylene glycol hexadecyl. When active pharmaceutical ingredients apis are classified according to the biopharmaceutics classification system more than 35% of commonly prescribed drugs are considered to be poorly watersoluble.
The excellent skin compatibility is proven and allergic skin reactions are not reported. Softisan 649 is a nonanimal derived semisolid lanolin substitute with high waterbinding capacity and good adhesion to the skin. Us4790989a us07036,929 us3692987a us4790989a us 4790989 a us4790989 a us 4790989a us 3692987 a us3692987 a us 3692987a us 4790989 a us4790989 a us 4790989a authority us united states prior art keywords salt mupirocin composition method pseudomonic acid prior art date 19860626 legal status the legal status is an assumption and is not a legal. An intranasal irritation assessment of antibacterial.
Bisdiglyceryl polyacyladipate2 is a partial ester of diglycerin with medium chain fatty acids, isostearic acid, stearic acid. Placebo verum 2% softisan 649 7 6 5 4 3 2 trade name inci placebo % verum % imwitor 372 p glyceryl stearate citrate 3. Safety assessment of bisdiglyceryl polyacyladipate2 and. With our two modern production facilities in germany with a combined capacity of more than 20. Softisan 649 bisdiglyceryl polyacyladipate2 jcic, dmf sticky paste 540 at 50 c semisolid lanolin substitute, emollient, high water binding capacity, good adhesion to skin, nonocclusive. Softisan 649,vegan lanolin substitute alexmo cosmetics. Cosmetics formulary 012012 foreword sasol is a leading producer of raw materials for cosmetics and personal care. An intranasal irritation assessment of antibacterial ointment. It is a nonanimal derived, vegetablebased semisolid lanolin substitute with high waterbinding capacity and good adhesion to the skin. Individuals receiving this information must utilize their independent judgment in determining. As far as we are aware softi are no longer trading. Phase behavior characterization of ointments containing lanolin or a lanolin substitute article in drug development and industrial pharmacy 1911. Eradication of meticillinresistant staphylococcus aureus.
It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. Softisan gc8 and softisan pg2 c10 can be used in emulsions, surfactantbased or hydroalcoholic formulations. Here you will find an overview of our products from the personal care range. The test article or vehicle was administered to all groups via topical administration to the external nares, twice a day approx. Bactroban is a white ointment in an aluminium tube. Softisan 649 1 bisdiglyceryl polyacyladipate2 10,00 cremervero shea butter 1 butyrospermum parkii butter 30,00 castor oil ricinus communis castor seed oil 10,00. Use the document link to view download the complete formulation document in adobe acrobat. Softisan 649 is a semisolid lanolin substitute with high water binding capacity and good adhesion to skin. In order to promote public education and public safety, equal justice for all, a better informed citizenry, the rule of law, world trade and world peace, this legal document is hereby made available on a noncommercial basis, as it is the right of all humans to know and speak the laws that govern them. Safety assessment of bisdiglyceryl polyacyladipate2 and bis. The present invention relates to a topical pharmaceutical composition comprising mupirocin and beclomethasone, processes for its preparation, and its use in the treatment of infected dermatoses caused by bacteria susceptible to mupirocin and in the treatment or prevention of secondary bacterial infections in patients of steroid responsive dermatoses.
Challenges and opportunities in the encapsulation of. In the event of any discrepancy between this information and the official information of wclc, the latter shall prevail. Scan to pdf as a replacement for softi scan to pdf software. Softisan 649 is a non animal derived semisolid lanolin substitute with high waterbinding capacity and.
Softisan 649 is used in baby care, lip products, protective creams and sun care. Softisan 649 familiarize yourself with this chemical and take. Softisan 649 is a partial ester of diglycerin with medium chain fatty acids, isostearic acid, stearic acid, 12hydroxystearic acid and adipic acid. Us5594026a us08424,684 us42468495a us5594026a us 5594026 a us5594026 a us 5594026a us 42468495 a us42468495 a us 42468495a us 5594026 a us5594026 a us 5594026a authority us united states prior art keywords mupirocin polymorph form crystalline form iii prior art date 19901211 legal status the legal status is an assumption and is not a legal conclusion. Marketing authorisation holder and manufacturer marketing authorisation holder. The softisan range consists of a modern lanolin substitute and other valuable functional excipients. Softisan 649 can improve the skin barrier by reducing the transepidermal water loss tewl. Formula information click on the component link for advanced information from the physicochemical database. We have gathered our activities for the pharmaceutical industry under the roof of ioi pharma, with strong commitment to quality leadership in oleoceuticals. What bactroban looks like and contents of the pack bactroban is a smooth offwhite ointment.
Phase behavior characterization of ointments containing. In the personal care division of ioi oleo gmbh, we have decades of experience in the production and application of specialties for cosmetics. The witepsol product range with its different types is the worldwide leading market standard for suppository bases adeps solidus. Customers should always refer to the ingredients label as affixed to each product or the material safety data sheet specification sheet which are current at the time of supply of the product.
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